Drug Delivery Systems

Drug delivery is the linchpin of modern therapeutics, with lipid nanoparticles (Acuitas, Genevant, Moderna SM-102) carrying mRNA and CRISPR payloads, and antibody-drug conjugates (Enhertu, Trodelvy, datopotamab deruxtecan) delivering cytotoxic warheads with unprecedented therapeutic indices. The track will examine extra-hepatic LNP targeting (SORT particles, GalNAc-conjugated systems for non-liver tissue), engineered exosomes (Codiak, Evox), polymer micelles, and stimuli-responsive depots. Oral biologics, intranasal CNS delivery, and ultrasound-mediated blood-brain barrier opening (Insightec) will be examined alongside the regulatory and CMC challenges of next-generation modalities.